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제목 |
Effect of Lepromin A on Prostaglandins production by Human Monocytes |
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저자 |
Gue Tae Chae, Shi Ryong Choi |
소속 |
Chronic Disease laboratory, Dept. of Pathology Catholic University Medical College |
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년도 |
1990 |
권 |
23 |
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호 |
1 |
번호 |
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시작페이지 |
48 |
끝페이지 |
54 |
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첨부 |
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요약 |
It is well established that prostaglandins, especially prostaglandin
E2(PGE2) are associated with monocyte and macrophage
functions and modulate responses of T lymphocyte. Recently it was reported that M.
leprae infected macrophage enhanced production of PGE2.
PGE2 probably depress cell mediated immunity in leprosy patients by
inhibition of interleukin-2(IL-2), interferon-gamma(IFNγ) production from lymphocytes
in the lepromatous granuloma.
In attempt to examine the possibility of lepromin A which comes of autoclaved M.
leprae from armadillo can cause increment of PGE2, lepromin A applied to
1×106 cells/well of monocytes isolated from peripheral blood by use of
Ficoll-Hypaque density gradient and gelatin coated flasks. Lepromin A induced increase
of PGE2 production selectively among cyclooxygenase metabolites of
monocytes with or without previous treatment of 800 units of IFNγ, 2,000 units of
IL-2. IFNγ, IL-2 caused decrease of PGE2 production of lepromin A
treated monocytes.
These results suggests that the selective increment of PGE2 production
depends on the antigenecity of M. leprae, not on the viability of M. leprae. |
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내용 |
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